Extending life span by increasing oxidative stress
نویسندگان
چکیده
منابع مشابه
Extending life-span in C. elegans.
The life-span of the nematode Caenorhabditis elegans can be extended by at least six different mechanisms, including calorie restriction, reduced Ins/IGF-1 signaling, germline ablation, food sensing amphid ablation, mitochondrial deficiency, and decreased temperature. Reduced Ins/IGF-1 signaling and calorie restriction can also increase the life-span of flies and mice. The Brevia "Healthy anima...
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When the food intake of organisms such as yeast and rodents is reduced (dietary restriction), they live longer than organisms fed a normal diet. A similar effect is seen when the activity of nutrient-sensing pathways is reduced by mutations or chemical inhibitors. In rodents, both dietary restriction and decreased nutrient-sensing pathway activity can lower the incidence of age-related loss of ...
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Hypertension, insulin resistance, and obesity are common age-related metabolic disorders that are often associated with increased oxidative stress and the resultant vascular damage. Underlying mechanisms have been suggested, and age-related overproduction of oxidative stress is one possible candidate. Since we recently found a vasoactive peptide, adrenomedullin, to be an endogenous antioxidant ...
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Evolutionary theories propose that aging is the result of a trade-off between self-maintenance and reproduction, and oxidative stress may play a crucial role in such a trade-off. Phenotypic manipulations have revealed that a high investment in reproduction leads to a decline in the organism's resistance to oxidative stress, which could in turn accelerate aging. Here, by using quantitative genet...
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BACKGROUND Oxidative stress is a probable cause of aging and associated diseases. Reactive oxygen species (ROS) originate mainly from endogenous sources, namely the mitochondria. METHODOLOGY/PRINCIPAL FINDINGS We analyzed the effect of aerobic metabolism on oxidative damage in Schizosaccharomyces pombe by global mapping of those genes that are required for growth on both respiratory-proficien...
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ژورنال
عنوان ژورنال: Free Radical Biology and Medicine
سال: 2011
ISSN: 0891-5849
DOI: 10.1016/j.freeradbiomed.2011.05.010